the antinociceptive effect of 17β-estradiol in the nucleus paragigantocellularis lateralis of male rats may be mediated by the nmda receptors
Authors
abstract
introduction: the nucleus paragigantocellularis lateralis (lpgi) is involved in the descending pain modulation. the neurostreoid, 17β-estradiol found in the pgi nucleus and modulates nociception by binding to estrogen receptors and also by allosteric interaction with nmda receptors. in this study, the role of nmda receptors in the 17β-estradiol-induced pain modulation was investigated by assessing the inflammatory pain responses changes after blockade of the lpgi nucleus’ nmda receptors. methods: in order to study the antinociceptive effect of intra-lpgi microinjection of 17β-estradiol, a guide cannula was implanted into the right lpgi nucleus. 500 nl of drugs were administered 15 minutes prior to formalin (50 μl of 4%) injection. then, formalin-induced paw jerking behaviour was recorded for 60 min. for assessing the role of the nmda receptors in the pain modulation by 17β-estradiol, it was injected 15 min after the intra-lpgi administration of 0.5 nmol of ap5 (the nmda receptor antagonist); and paw jerking frequency was recorded for 1 h. results: the results of the present study showed that intra-lpgi injection of 0.8 μmol of 17β-estradiol attenuated the chronic phase (p<0.001) of paw jerking behaviour. ap5 significantly reduced the antinociceptive effect of intra-lpgi 17β-estradiol both in the acute (p<0.001) and in the chronic phase (p<0.001) of formalin test. conclusion: according to the results of this study, it can be concluded that the analgesic effect of intra-lpgi injection of 17β-estradiol on the formalin-induced inflammatory pain might be mediated via nmda receptors.
similar resources
The antinociceptive effect of 17β-estradiol in the nucleus paragigantocellularis lateralis of male rats may be mediated by the NMDA receptors
Introduction: The nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. The neurostreoid, 17β-estradiol found in the PGi nucleus and modulates nociception by binding to estrogen receptors and also by allosteric interaction with NMDA receptors. In this study, the role of NMDA receptors in the 17β-estradiol-induced pain modulation was investig...
full textThe antinociceptive effect of 17β-estradiol in the paragigantocellularis lateralis of male rats is mediated by estrogenic receptors
Introduction: 17β-Estradiol is a neuroactive steroid and its pain modulatory role has been well studied previously. 17β-Estradiol modulates nociception by binding to its receptors and also by allosteric interaction with other membrane - bound receptors such as glutamate and GABAA receptors. Paragigantocellularis lateralis (LPGi) is also involved in pain modulation and perception, in addition...
full textAnalgesic Effect of 17β-Estradiol on Nucleus Paragigantocellularis Lateralis of Male Rats Mediated Via GABAA Receptors
Introduction: Beside its autonomic functions, the nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. 17β-Estradiol is a neuroactive steroid found in several brain areas such as LPGi. Intra-LPGi microinjection of 17β-estradiol can elicit the analgesic responses. 17β-Estradiol modulates nociception by binding to estrogenic receptors as wel...
full textThe antinociceptive effect of 17β-estradiol in the nucleus paragigantocellularis lateralis of male rats may be mediated by the NMDA receptors
Introduction: The nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. The neurostreoid, 17β-estradiol found in the PGi nucleus and modulates nociception by binding to estrogen receptors and also by allosteric interaction with NMDA receptors. In this study, the role of NMDA receptors in the 17β-estradiol-induced pain modulation was investigated by assess...
full textAnalgesic Effect of 17β-Estradiol on Nucleus Paragigantocellularis Lateralis of Male Rats Mediated Via GABAA Receptors
INTRODUCTION Beside its autonomic functions, the nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. 17β-Estradiol is a neuroactive steroid found in several brain areas such as LPGi. Intra-LPGi microinjection of 17β-estradiol can elicit the analgesic responses. 17β-Estradiol modulates nociception by binding to estrogenic receptors as well as allosteric ...
full textThe role of GABAA receptors in the analgesic effect of intra-paragigantocellularis lateralis injection of 17β-estradiol in male rat
Introduction: 17&beta-Estradiol modulates nociception by binding to the estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and GABAA receptors. In addition to its autonomic functions, paragigantocellularis lateralis (LPGi) is involved in the pain modulation, too. The aim of the current study was to investigate the involvement of the membra...
full textMy Resources
Save resource for easier access later
Journal title:
physiology and pharmacologyجلد ۲۰، شماره ۲، صفحات ۱۲۲-۱۲۹
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023